HOME
The Institute of Physiology and Pathophysiology of Heidelberg
University is inviting applications for PhD position to work on zyxin
control of stretch-induced arterial remodelling at Hartmut
Hoffmann-Berling International Graduate School of Molecular and Cellular
Biology (HBIGS). The position will come with a yearly living
allowance. The project includes several weeks of training with
collaborators in Amsterdam (Netherlands) and Münster within the
framework of the Marie Curie Initial Training Network “SmArteR”.
Applicant must have spent less than 12 months in Germany in the last
three years (though no restrictions on citizenship) to be eligible for
this position.
Study Subject(s): This position is available to work on zyxin control of stretch-induced arterial remodelling.
Course Level: This position is available for pursuing PhD program at Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS) of Heidelberg University.
Scholarship Provider: The Institute of Physiology and Pathophysiology of Heidelberg University
Scholarship can be taken at: Germany (The project includes several weeks of training with collaborators in Amsterdam (Netherlands) and Münster within the framework of the Marie Curie Initial Training Network “SmArteR”.)
Eligibility:
-Must have spent less than 12 months in Germany in the last three years (though no restrictions on citizenship)
-Master or diploma in biology, biochemistry or related fields
-Knowledge of cell biological, molecular biological as well as biochemical techniques or willingness to acquire the necessary skills
-Team-minded and flexible
-Ability to rapidly familiarize him/herself with new research areas in theory and praxis
Scholarship Open for International Students: International students (must have spent less than 12 months in Germany in the last three years) can apply for this position.
Scholarship Description: The Institute of Physiology and Pathophysiology of Heidelberg University, Division of Cardiovascular Physiology (Prof. Dr. Markus Hecker) offers a PhD position to work on zyxin control of stretch-induced arterial remodelling. The focal adhesion molecule zyxin specifically translocates to the nucleus of vascular cells in response to stretch or hypertension. In the nucleus, the protein orchestrates expression of a majority of stretch-/pressure-induced genes, among which mRNAs encoding for matrix proteins and ECM modifying enzymes are prominent. Aged zyxin-deficient mice show a reorientation of the arterial smooth muscle cells (SMCs) in response to hypertension, associated with a more pronounced pressure-induced passive distension and a failure to up-regulate blood pressure. It appears that adult zyxin-deficient mice develop a severe deficit in arterial contractility due to a marked alteration in matrix composition and that the stretch-sensitive transcription factor zyxin has a major impact on the control of vascular SMC phenotype. The project will investigate the role of zyxin-controlled ECM proteins and matrix-modifying enzymes in pressure-induced vascular remodeling both in vitro and in vivo.
What does it cover? The position will come with a yearly living allowance in accordance with the regulations specified by the European Commission for Marie Curie Initial Training Networks.
How to Apply: Please submit your application via the HBIGS website.
Scholarship Application Deadline: The application deadline is August 17 2013.
Further Official Scholarship Information and Application
Study Subject(s): This position is available to work on zyxin control of stretch-induced arterial remodelling.
Course Level: This position is available for pursuing PhD program at Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS) of Heidelberg University.
Scholarship Provider: The Institute of Physiology and Pathophysiology of Heidelberg University
Scholarship can be taken at: Germany (The project includes several weeks of training with collaborators in Amsterdam (Netherlands) and Münster within the framework of the Marie Curie Initial Training Network “SmArteR”.)
Eligibility:
-Must have spent less than 12 months in Germany in the last three years (though no restrictions on citizenship)
-Master or diploma in biology, biochemistry or related fields
-Knowledge of cell biological, molecular biological as well as biochemical techniques or willingness to acquire the necessary skills
-Team-minded and flexible
-Ability to rapidly familiarize him/herself with new research areas in theory and praxis
Scholarship Open for International Students: International students (must have spent less than 12 months in Germany in the last three years) can apply for this position.
Scholarship Description: The Institute of Physiology and Pathophysiology of Heidelberg University, Division of Cardiovascular Physiology (Prof. Dr. Markus Hecker) offers a PhD position to work on zyxin control of stretch-induced arterial remodelling. The focal adhesion molecule zyxin specifically translocates to the nucleus of vascular cells in response to stretch or hypertension. In the nucleus, the protein orchestrates expression of a majority of stretch-/pressure-induced genes, among which mRNAs encoding for matrix proteins and ECM modifying enzymes are prominent. Aged zyxin-deficient mice show a reorientation of the arterial smooth muscle cells (SMCs) in response to hypertension, associated with a more pronounced pressure-induced passive distension and a failure to up-regulate blood pressure. It appears that adult zyxin-deficient mice develop a severe deficit in arterial contractility due to a marked alteration in matrix composition and that the stretch-sensitive transcription factor zyxin has a major impact on the control of vascular SMC phenotype. The project will investigate the role of zyxin-controlled ECM proteins and matrix-modifying enzymes in pressure-induced vascular remodeling both in vitro and in vivo.
What does it cover? The position will come with a yearly living allowance in accordance with the regulations specified by the European Commission for Marie Curie Initial Training Networks.
How to Apply: Please submit your application via the HBIGS website.
Scholarship Application Deadline: The application deadline is August 17 2013.
Further Official Scholarship Information and Application
0 comments:
Post a Comment